Serin 2018
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23 October 2018
13h00Opening address: Claus Bachert
13h10 - 16h10SESSION 1
Invited Lectures
13h10Microvesicles in airway inflammationAdam Ceroi
13h55Staphylococcus aureus in airway disease: allergen – superallergen – superantigen? Barbara Bröker
14h40The interplay of the staphylococcal protease SplD and IL-33 in the development of allergic asthma in miceAndrea Teufelberger, Olga Krysko
15h25Tissue remodelling and new approaches to treatmentRobert Schleimer
16h10Coffee break
16h30 – 18h30SESSION 2
Invited Lectures
16h30ILCs one two three! Koen van Crombruggen
17h10Neuropeptides and innate immunityLars-Olaf Cardell
17h50Barrier function in CRSwNPRobert Schleimer
18h30Walking Dinner

24 October 2018
9h00–12h00SESSION 3
Invited Lectures
9h00Antisense therapy in upper airway inflammationHarald Renz
9h45Charcot-Leyden crystals in persistent airway disease Bart Lambrecht
10h30Local and systemic IgE repertoires in allergic rhinitis and nasal polyps Hannah Gould
Short oral presentations
11h15Blocking histone deacetylase activity as a novel treatment for epithelial barrier dysfunction in allergic rhinitis and asthma Steelant B. 1,2, Wawrzyniak P. 2, Martens K. 1, Krawczyk K. 2, Dreher A. 2, Akdis AA. 2, Hellings PW. 1,3
1 Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; 2 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland; 3 Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Belgium
11h25Targeted metabolomics and DNA methylation analysis reveal overlapping metabolic signatures in aspirin-tolerant and aspirin-intolerant CRSwNP patients Haimerl P. 1, Bernhardt U. 1,2, Henkel F. 1, Friedl A. 1, Haid M. 3, Cecil A. 3, Busato F. 4, Prehn C. 3, Tost J. 4, Adamski J. 3, Schmidt-Weber C. 1, Chaker A. M. 1,2, Esser-Von Bieren J. 1
1 ZAUM - Center of Allergy & Environment Munich, Technical University and Helmholtz Center Munich, Munich, Germany; 2 Department of Otolaryngology, Klinikum rechts der Isar, Munich, Germany; 3 Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; 4 CEA-Institut de Biologie Francois Jacob, Centre National de Recherche en Génomique Humaine, Evry, France
11h35Toll-like receptor 9 ligands increase type I interferon induced B-cell activating factor expression in chronic rhinosinusitis with nasal polyposis. Kim Y.M., Xu J., Lee J.-W., Yoon Y.H., Yeon S.-H., Park S.-K.
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University School of Medicine, Daejeon, Korea
11h45Lunch
12h30Poster session
13h00 – 16h00SESSION 4
Invited Lectures
13h00The many faces of Eosinophils in upper airway disease Elien Gevaert
13h45Does the type of cell death matter?Dmitri Krysko
14h30Microbiome and allergic disease in early life Ruby Pawankar
15h15Viral infections in the development of chronic upper airway diseaseEugene Chang
16h00Coffee break
16h30 – 18h30SESSION 5
Invited Lectures
16h30Mechanisms in AIT – Latest update Mohamed Shamji
17h00Novel approaches and the future of AIT Stephen Durham
17h30Monoclonals in allergic rhinitis - Feld 1-specific IgG4 antibodies are effective! Mohamed Shamji
Short oral presentations
18h00Attenuation of pro-inflammatory IL-4+IL-21+ T follicular helper cells and induction of FoxP3+ T follicular regulatory cells following a short-course Lolium perenne peptide immunotherapy treatment Sharif H. 1,2, Gabriele H. 3, Derycke L. 3, Duchateau J. 4, Legon T. 4, Pirotton S. 4, Mösges R. 5, Durham S.R. 1,2, Bachert C. 3, Shamji M.H. 1,2
1 Immunomodulation and Tolerance Group, Immune Tolerance Network (ITN) Distributed Centre of Excellence for Allergy & Asthma, Allergy & Clinical Immunology Inflammation, Repair and Development National Heart & Lung Institute, Imperial College London; 2 MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom; 3 Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 4 ASIT biotech s.a., Brussels, Belgium; 5 Institute of Medical Statistics, Informatics and Epidemiology (IMSIE), Cologne, Germany
18h10Role of IL-33 signaling in pollutant-induced allergic airway inflammation Maes T. 1, De Grove K.C. 1, Provoost S. 1, Braun H. 2,3, Teufelberger A.R. 4, Krysko O. 4, Beyaert R. 2,3, Brusselle G.G.1, Joos G.F.1, Maes T.1
1 Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium; 2 Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium; 3 Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; 4 Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
18h20Role of Interleukin (IL)-35 in Allergic Rhinitis and Following Allergen Immunotherapy Layhadi J.A. 1,2, Achkova D. 1,2, Kouser L. 1,2, Perera-Webb A. 1,2, Couto-Francisco N. 1,2, Parkin R.V. 1,2, Matsuoka T. 1,2, Scadding G. 1,2, Durham S.R. 1,2 and Shamji M.H. 1,2
1 Imperial College London, UK; 2 Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK

25 October 2018
8h30 – 13h45SESSION 6
Invited Lectures
8h30Plasma cells and B regulation Mübeccel Akdis
9h10Biologics will change the rhinologist’s world! Claus Bachert
9h50IL-5Ralpha antagonism in airway diseasePaul Newbold
10h30Coffee Break
10h50What can we learn from asthma and COPD for CRS?Peter Howarth
11h30The IL-4Ralpha as turning point for type 2 disease tba
12h10The pathophysiology of IgE and anti-IgE Xianbin Tian (Novartis)
Discussion
12h50Status and the future in biologics for CRS – the questions to solve

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Serin 2018
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